Sulfadiazine-Trimethoprim
Brands: Tribrissen, Bactrim
Sulfadiazine-Trimethoprim is a potent antibiotic used in pets for bacterial infections.
Used for
- respiratory infections
- urinary tract infections
- skin infections
How it is given
- Administration
- oral
- Frequency
- twice daily
- Duration
- 7-14 days
- Storage
- Store in a cool, dry place away from light.
- Pregnancy safety
- caution
Always confirm the exact dose with your veterinarian before giving any medicine.
Typical dose ranges
cat
- Standard
- 12 mg/lb per day
dog
- Large dogs
- 10 mg/lb per day
- Small dogs
- 15 mg/lb per day
- Medium dogs
- 12 mg/lb per day
Ranges are reference only. Your vet sets the dose for your pet's weight and condition.
Active ingredients
- Sulfadiazine
- Trimethoprim
Side effects
Common
- loss of appetite
- vomiting
Rare
- anemia
Severe
- allergic reactions
Do not use when
- liver disease
- kidney disease
Interacts with
- Methotrexate
- Warfarin
Warnings
- Monitor for allergic reactions
- Adjust dose in renal impairment
Sulfadiazine-Trimethoprim questions
Can this medication be given with food?
Yes, it is recommended to be given with food.
Are there any dietary restrictions?
No specific dietary restrictions unless directed by a veterinarian.
How should I store the medication?
Keep it in a cool, dry place, away from light.
What happens if my pet misses a dose?
Give the missed dose as soon as remembered unless it is close to the next dose.
Is it safe for long-term use?
Long-term use should be monitored by a veterinarian.
Full drug detail
Overview
Sulfadiazine-Trimethoprim is a combination antibiotic used in veterinary medicine to treat a variety of bacterial infections in pets. It combines two active ingredients to effectively inhibit bacterial growth.
How It Works
This medication works by combining sulfadiazine, a sulfonamide, with trimethoprim, a dihydrofolate reductase inhibitor. Together, they block bacterial synthesis of folic acid, essential for bacterial growth and replication.
Uses & Indications
Sulfadiazine-Trimethoprim is indicated for:
- Respiratory infections
- Urinary tract infections
- Skin infections
- Gastrointestinal infections
Dosage Guidelines
Dogs
- Small Dogs: 15 mg/lb (30 mg/kg) per day
- Medium Dogs: 12 mg/lb (25 mg/kg) per day
- Large Dogs: 10 mg/lb (20 mg/kg) per day
Cats
- Standard: 12 mg/lb (25 mg/kg) per day
Administration
This medication is administered orally and should be given with food to reduce gastrointestinal upset.
Side Effects
Common
- Loss of appetite
- Vomiting
Rare
- Anemia
Severe
- Allergic reactions (swelling, difficulty breathing)
Precautions & Warnings
- Not for use in animals with liver or kidney disease
- Avoid in animals with a known allergy to sulfonamides
Drug Interactions
- Methotrexate: May increase toxicity
- Warfarin: Enhanced anticoagulant effect
Storage
Store in a cool, dry place away from direct sunlight.
FAQ
-
What should I do if a dose is missed? Administer as soon as remembered unless close to the next dose.
-
Can it be used in pregnant pets? Use with caution and only under veterinary supervision.
-
What if an overdose occurs? Contact a veterinarian immediately.
-
How long does it take to see improvement? Improvement is typically seen within a few days.
-
Is a prescription required? Yes, a prescription is needed.
Drug Interactions
- Methotrexate: Increased toxicity risk
- Phenytoin: Increased serum levels
Storage
Store in a tightly sealed container at room temperature.
FAQs
-
Can this medication be given with food? Yes, it is recommended to be given with food.
-
Are there any dietary restrictions? No specific dietary restrictions unless directed by a veterinarian.
-
How should I store the medication? Keep it in a cool, dry place, away from light.
-
What happens if my pet misses a dose? Give the missed dose as soon as remembered unless it is close to the next dose.
-
Is it safe for long-term use? Long-term use should be monitored by a veterinarian.