Skip to content
All medicines

Trazodone

Brands: Desyrel, Oleptro

Trazodone is a sedative used in pets to manage anxiety and behavioral issues.

Prescription requiredserotonin antagonist and reuptake inhibitor (SARI)sedativedogcat

Used for

  • anxiety
  • behavioral issues
  • situational stress

How it is given

Administration
oral
Frequency
once or twice daily
Duration
as prescribed by a veterinarian
Storage
Store at room temperature away from moisture and light.
Pregnancy safety
caution

Always confirm the exact dose with your veterinarian before giving any medicine.

Typical dose ranges

cat

Standard
25-50 mg per cat

dog

Large dogs
3-5 mg/kg
Small dogs
3-5 mg/kg
Medium dogs
3-5 mg/kg

Ranges are reference only. Your vet sets the dose for your pet's weight and condition.

Active ingredients

  • trazodone hydrochloride

Side effects

Common

  • sedation
  • lethargy
  • gastrointestinal upset

Rare

  • priapism

Severe

  • seizures or severe behavioral changes

Do not use when

  • hypersensitivity to trazodone
  • liver impairment

Interacts with

  • MAO inhibitors
  • other serotonin-affecting medications

Warnings

  • Use caution in pets with liver or kidney impairment
  • Avoid use in pets with hypersensitivity

Trazodone questions

What should I do if I miss a dose?

Administer the missed dose as soon as you remember unless it's close to the next scheduled dose.

Can trazodone be used long-term?

Yes, but only under the guidance of a veterinarian.

What if my pet overdoses?

Contact your veterinarian immediately or visit an emergency clinic.

Is trazodone safe for puppies or kittens?

Use with caution, and only if prescribed by a veterinarian.

Can trazodone be used with other medications?

Yes, but inform your veterinarian about all other medications your pet is taking.

Full drug detail

Overview

Trazodone is a prescription medication commonly used in veterinary medicine to manage anxiety, behavioral issues, and stress in pets, particularly dogs and cats. It serves as a serotonin antagonist and reuptake inhibitor (SARI), impacting serotonin levels in the brain to help improve mood and behavior.

How It Works

Trazodone works by inhibiting the reuptake of serotonin, a neurotransmitter that plays a key role in mood regulation. This action increases serotonin levels in the brain, contributing to its calming effects.

Uses & Indications

Trazodone is primarily used to treat:

  • Anxiety
  • Fear-based behaviors
  • Situational stress (e.g., thunderstorms, fireworks)

Dosage Guidelines

Dogs

  • Small Dogs: 3-5 mg/kg
  • Medium Dogs: 3-5 mg/kg
  • Large Dogs: 3-5 mg/kg

Cats

  • Standard Dosage: 25-50 mg per cat, depending on the specific case.

Administration

Trazodone is administered orally in tablet form. It is typically given once or twice daily, depending on the severity of the condition and the veterinarian's instructions.

Side Effects

Common

  • Sedation
  • Lethargy
  • Gastrointestinal upset

Rare

  • Priapism (prolonged erection in males)

Severe

  • Seizures or severe behavioral changes should prompt immediate veterinary attention.

Precautions & Warnings

  • Trazodone should not be used in pets with hypersensitivity to the drug.
  • Use caution in animals with liver or kidney impairment.

Drug Interactions

  • MAO inhibitors
  • Other serotonin-affecting medications

Storage

Store trazodone at room temperature away from moisture and light.

FAQ

  • What should I do if I miss a dose? Administer the missed dose as soon as you remember unless it's close to the next scheduled dose.

  • Can trazodone be used long-term? Yes, but only under the guidance of a veterinarian.

  • What if my pet overdoses? Contact your veterinarian immediately or visit an emergency clinic.

  • Is trazodone safe for puppies or kittens? Use with caution, and only if prescribed by a veterinarian.

  • Can trazodone be used with other medications? Yes, but inform your veterinarian about all other medications your pet is taking.

Back